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anlotinib + toripalimab
- Development stage
- Unknown
- Lead developer
- Chia Tai-Tianqing Pharmaceutical Group
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Oral, Intravenous
01
Overview
Anlotinib + toripalimab is a combination therapy consisting of two distinct agents used primarily in oncology. Anlotinib is a small molecule multi-targeted tyrosine kinase inhibitor that inhibits angiogenesis and tumor cell proliferation by targeting receptors such as VEGFR, FGFR, PDGFR, and c-Kit. Toripalimab is a recombinant humanized monoclonal antibody that targets the programmed cell death protein 1 (PD-1) receptor on T cells, functioning as an immune checkpoint inhibitor to enhance anti-tumor immune responses. This combination has shown promising efficacy and manageable safety in several cancer types including unresectable hepatocellular carcinoma (HCC), advanced gastric or gastroesophageal junction carcinoma, metastatic melanoma, advanced esophageal squamous cell carcinoma (ESCC), undifferentiated pleomorphic sarcoma (UPS), and extensive-stage small-cell lung cancer (ES-SCLC). The regimen leverages the synergistic effects of antiangiogenic therapy with immunotherapy to improve clinical outcomes[1][3][4][5][6][7].
- Brand names
- TuoyiFukanghua
- Other names
- anlotinib plus toripalimabtoripalimab plus anlotinib
02
Targets
FGFR4 (Fibroblast growth factor receptor 4)KIT (c-KIT proto-oncogene receptor tyrosine kinase)PDGFRA (Platelet-derived growth factor receptor alpha)PDCD1 (Programmed cell death protein 1 receptor)PDGFRB (Platelet-derived growth factor receptor beta)FGFR3 (Fibroblast growth factor receptor 3)VEGFR3 (Vascular endothelial growth factor receptor 3)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)FGFR1 (Fibroblast growth factor receptor 1)FGFR2 (Keratinocyte growth factor receptor)
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