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anlotinib + doxorubicin
- Development stage
- Unknown
- Lead developer
- Chia Tai-Tianqing Pharmaceutical Group
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
Anlotinib + doxorubicin is an investigational combination regimen being developed for the neoadjuvant treatment of high-grade soft tissue sarcoma (STS). Anlotinib is a small-molecule, oral, multi-target tyrosine kinase inhibitor (TKI) that inhibits vascular endothelial growth factor receptors (VEGFR1, VEGFR2, VEGFR3), fibroblast growth factor receptors (FGFR1, FGFR2, FGFR3, FGFR4), platelet-derived growth factor receptors (PDGFRα, PDGFRβ), and c-Kit, thereby exerting anti-angiogenic and anti-tumor effects. Doxorubicin is a small-molecule anthracycline antibiotic and cytotoxic chemotherapy agent that intercalates into DNA and inhibits topoisomerase II, leading to DNA damage and apoptosis. The combination is currently being evaluated in a single-arm, prospective clinical study (NCT05747521) at Henan Cancer Hospital, often in conjunction with radiotherapy, to assess its efficacy and safety as a pre-surgical treatment for patients with high-grade soft tissue sarcoma.
- Brand names
- FukeweiAdriamycin
- Other names
- anlotinib hydrochloride + doxorubicin
02
Targets
TOP2A (DNA topoisomerase II)VEGFR2 (Vascular endothelial growth factor receptor 2)VEGFR-1 (Vascular endothelial growth factor receptor 1)DNAVEGFR3 (Vascular endothelial growth factor receptor 3)PDGFRB (Platelet-derived growth factor receptor beta)KIT (c-KIT proto-oncogene receptor tyrosine kinase)FGFR1 (Fibroblast growth factor receptor 1)RET (Rearranged during transfection receptor tyrosine kinase)
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