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anlotinib + transcatheter arterial chemoembolization
- Development stage
- Unknown
- Lead developer
- Chia Tai-Tianqing Pharmaceutical Group
- Modality
- Small Molecules
- Administration
- Oral, Intra-arterial
01
Overview
Anlotinib is a novel small-molecule multi-kinase inhibitor that selectively targets vascular endothelial growth factor receptors (VEGFR1/2/3), fibroblast growth factor receptors (FGFR1/2/3/4), platelet-derived growth factor receptors (PDGFRα/β), and c-Kit. Developed by Chia Tai Tianqing Pharmaceutical Group, it functions as an anti-angiogenic and anti-tumor agent. In the context of the ALTER-H004 trial, anlotinib is being evaluated in combination with transcatheter arterial chemoembolization (TACE) as an adjuvant therapy for patients with advanced hepatocellular carcinoma (HCC) who are at high risk of recurrence following surgical resection. The regimen typically involves a TACE procedure followed by oral administration of anlotinib hydrochloride.
- Brand names
- Fukanghua
- Other names
- anlotinib hydrochlorideTACE
02
Targets
VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)VEGFR4 (Vascular endothelial growth factor Receptor-3)KIT (c-KIT proto-oncogene receptor tyrosine kinase)FGFR1 (Fibroblast growth factor receptor 1)FGFR2 (Keratinocyte growth factor receptor)FGFR3 (Fibroblast growth factor receptor 3)FGFR4 (Fibroblast growth factor receptor 4)PDGFRA (Platelet-derived growth factor receptor alpha)PDGFRB (Platelet-derived growth factor receptor beta)
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