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annexin A8 siRNA
- Development stage
- Preclinical
- Lead developer
- H. Lee Moffitt Cancer Center & Research Institute
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intratumoral
01
Overview
Annexin A8 siRNA is a small interfering RNA (siRNA) designed to silence the expression of the Annexin A8 (ANXA8) gene. Annexin A8 is a member of the annexin family of calcium-dependent phospholipid-binding proteins, which are involved in various cellular processes including vesicle trafficking, cell signaling, and growth regulation. In the context of pancreatic cancer, Annexin A8 has been identified as a gene associated with tumor differentiation and a potential prognostic marker; high expression levels correlate with poor survival outcomes in early-stage patients. Mechanistic studies using Annexin A8 siRNA in pancreatic cancer cell lines, such as BXPC-3, have demonstrated that knockdown of this protein leads to significant reductions in cell viability, migration, and colony formation, suggesting that Annexin A8 plays a critical role in tumor progression and could serve as a viable therapeutic target.
- Other names
- Annexin A8 siRNAA-A8 siRNAA-A-8 siRNAA-A 8 siRNAANXA8 siRNAANXA-8 siRNAANXA 8 siRNA
02
Targets
ANXA8
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