Drug intelligence / Profile preview

annovera

Development stage
Approved
Lead developer
Population Council
Modality
Small Molecules
Administration
Vaginal
01

Overview

Annovera is a reusable, silicone-based contraceptive vaginal ring that contains two hormones—segesterone acetate (a progestin) and ethinyl estradiol (an estrogen). It is designed for female contraception and works primarily by suppressing ovulation. The ring is inserted into the vagina for 21 days, followed by a 7-day break, in repeated cycles for up to one year (13 cycles total). Annovera provides long-acting, patient-controlled birth control without requiring any procedures or device implantation. Its mechanism of action involves inhibition of ovulation through suppression of gonadotropins; it also causes changes in cervical mucus and endometrial lining to prevent sperm penetration and implantation[2][3][4][7].

Brand names
Annovera
Other names
segesterone acetate and ethinyl estradiol vaginal systemsegesterone acetate/ethinyl estradiol vaginal ring
02

Targets

PR (Progesterone receptor)ER (Estrogen receptor)

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