ANO1 shRNA

ANO1 shRNA is a research-stage gene-silencing tool that utilizes short hairpin RNA (shRNA) to knock down the expression of Anoctamin 1 (ANO1), also known as TMEM16A or DOG1. ANO1 is a calcium-activated chloride channel that is frequently overexpressed in various cancers, including glioma, prostate cancer, and colorectal cancer, where it contributes to tumorigenesis, proliferation, migration, and invasion. In preclinical studies, ANO1 shRNA has been shown to suppress the maintenance of stemness and increase radiation sensitivity in glioma stem cells by stabilizing EGFRvIII. It is typically delivered via lentiviral particles or plasmids and has demonstrated the ability to significantly inhibit tumor growth in intracranial and xenograft mouse models. While commercially available from reagent suppliers such as Santa Cruz Biotechnology and Sigma-Aldrich for non-commercial research use, it is not currently a clinical-stage therapeutic asset.

Other names

TMEM16A shRNATMEM-16A shRNATMEM 16A shRNADOG1 shRNADOG-1 shRNADOG 1 shRNAAnoctamin-1 shRNAAnoctamin1 shRNAAnoctamin 1 shRNA