Anopyxis klaineana extract

Anopyxis klaineana extract is a botanical extract derived from the stem bark of the West African ethnomedicinal tree *Anopyxis klaineana*. It is primarily being investigated for its potential therapeutic applications as an antiparasitic agent against *Trypanosoma brucei*, the causative agent of African trypanosomiasis (sleeping sickness). In vitro and in silico studies have demonstrated that the extract and its active fractions (such as hexane, chloroform, and ethyl acetate) exhibit significant antitrypanosomal activity. The mechanism of action is believed to involve the inhibition of key parasite enzymes, specifically trypanothione reductase (TR) and uridine diphosphate galactose 4'-epimerase (TbGalE), which are essential for the parasite's survival. Additionally, the extract has shown potential anti-inflammatory, analgesic, and antidepressant-like properties in preclinical animal models.

Other names

Anopyxis klaineana stem bark extractEAK