anr-94

**ANR-94** is a highly selective antagonist of the adenosine A2A receptor (AA2AR), with a Ki of 46 nM for the human receptor. It is characterized as a potent antiparkinsonian agent in preclinical models, demonstrating improvements in parkinsonian motor deficits and tremor. Additionally, ANR-94 exhibits neuroprotective and anti-inflammatory effects in animal models of Parkinson's disease, protecting dopaminergic neurons from degeneration and reducing neuroinflammation. Its effects are primarily mediated by blockade of the adenosine A2A receptor, which is implicated in the control of motor function and neuroinflammation in the brain[1][3][5].

Other names

8-ethoxy-9-ethyladenine