Drug intelligence / Profile preview

ansornitinib

Development stage
Discontinued
Lead developer
Elicio Therapeutics
Modality
Small Molecules
Administration
Oral
01

Overview

Ansornitinib (ANG-3070) is an orally bioavailable, small molecule multi-kinase inhibitor developed by Angion Biomedica for the treatment of fibrotic diseases. It primarily targets the platelet-derived growth factor receptor (PDGFR) and fibroblast growth factor receptor (FGFR) families, which are key mediators in the pathogenesis of fibrosis. The drug was evaluated in clinical trials for primary glomerular diseases, such as focal segmental glomerulosclerosis (FSGS), and idiopathic pulmonary fibrosis (IPF). However, in early 2023, Angion Biomedica suspended the clinical development of its pipeline, including ANG-3070, following a merger agreement with Elicio Therapeutics.

Other names
ansornitinibANG-3070ANG3070ANG 3070
02

Targets

VEGFR2 (Vascular endothelial growth factor receptor 2)PDGFRA (Platelet-derived growth factor receptor alpha)PDGFRB (Platelet-derived growth factor receptor beta)FGFR1 (Fibroblast growth factor receptor 1)DDR1 (Discoidin domain receptor 1)DDR2 (Discoidin domain receptor tyrosine kinase 2)

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