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ansornitinib
- Development stage
- Discontinued
- Lead developer
- Elicio Therapeutics
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Ansornitinib (ANG-3070) is an orally bioavailable, small molecule multi-kinase inhibitor developed by Angion Biomedica for the treatment of fibrotic diseases. It primarily targets the platelet-derived growth factor receptor (PDGFR) and fibroblast growth factor receptor (FGFR) families, which are key mediators in the pathogenesis of fibrosis. The drug was evaluated in clinical trials for primary glomerular diseases, such as focal segmental glomerulosclerosis (FSGS), and idiopathic pulmonary fibrosis (IPF). However, in early 2023, Angion Biomedica suspended the clinical development of its pipeline, including ANG-3070, following a merger agreement with Elicio Therapeutics.
- Other names
- ansornitinibANG-3070ANG3070ANG 3070
02
Targets
DDR1 (Discoidin domain receptor 1)DDR2 (Discoidin domain receptor tyrosine kinase 2)FGFR1 (Fibroblast growth factor receptor 1)PDGFRA (Platelet-derived growth factor receptor alpha)PDGFRB (Platelet-derived growth factor receptor beta)VEGFR2 (Vascular endothelial growth factor receptor 2)FGFR2 (Keratinocyte growth factor receptor)FGFR3 (Fibroblast growth factor receptor 3)
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