antagomiR-467a-3p

AntagomiR-467a-3p is a chemically modified antisense oligonucleotide (antagomiR) designed to selectively bind and inhibit the microRNA miR-467a-3p[6][4]. In preclinical studies, antagomiR-467a-3p is shown to improve the stemness (self-renewal capacity) and myogenesis (muscle formation ability) of satellite cells (SCs), which are crucial for muscle maintenance and regeneration, particularly relevant to age-related conditions such as sarcopenia[1][4]. Its therapeutic profile involves the use of extracellular vesicle (EV) delivery systems or hydrogels for targeted, sustained release in vivo, leading to increased expression of genes like Klf4 and Sox2 and promotion of muscle repair and regeneration[1][4]. The core mechanism is specific inhibition of miR-467a-3p function at the RNA level, leading to modulation of gene pathways involved in cell proliferation and differentiation.

Other names

mmu-miR-467a-3p antagomirmmu-miR467a-3p antagomirmmu-miR 467a-3p antagomirmmu-miR-467a-3p inhibitormmu-miR467a-3p inhibitormmu-miR 467a-3p inhibitor