Drug intelligence / Profile preview

antaitavir hasophate + yiqibuvir

Development stage
Unknown
Lead developer
Sunshine Lake Pharma
Modality
Small Molecules
Administration
Oral
01

Overview

A fixed-dose oral combination of **antaitavir hasophate** and **yiqibuvir** developed for the treatment of **chronic hepatitis C virus (HCV) infection** in adults, including those with genotypes 1, 2, 3, and 6, with or without compensated cirrhosis, both in treatment-naive and treatment-experienced patients. Both agents act as **direct-acting antivirals** with distinct antiviral targets; antaitavir hasophate is described as an **imidazole derivative** (specific mechanistic class unspecified in literature), while yiqibuvir is reported as an antiviral targeting HCV replication. Clinical studies demonstrate high sustained virologic response rates and good safety profile, with most adverse events being mild. The combination is administered orally, once daily, in studies over 12-week periods, and has reached phase III clinical trial status in China[1][3][5][6].

Brand names
Antaitavir
Other names
antaitasvir phosphate + yiqibuvir
02

Targets

NS5A (Hepatitis C virus nonstructural protein 5A (genotype 1b))NS5B (Hepatitis C virus non-structural protein 5B (NS5B) RNA-dependent RNA polymerase)

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