Drug intelligence / Profile preview

Antengene SCLC trispecific antibody

Development stage
Preclinical
Lead developer
Antengene
Modality
T-cell Engagers → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Trispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
Administration
Intravenous
01

Overview

Antengene's undisclosed trispecific antibody for small cell lung cancer (SCLC) is a therapeutic candidate developed using the company's proprietary **AnTenGager™ TCE 2.0 platform**. As a T-cell engager (TCE), the antibody is designed to bridge T-cells with tumor cells, facilitating targeted immune-mediated destruction of the cancer. While the specific tumor-associated antigens targeted by this molecule have not been publicly disclosed, the trispecific format typically allows for enhanced binding specificity or the incorporation of costimulatory domains to improve the therapeutic window and anti-tumor activity. The program is currently in the preclinical stage of development as part of Antengene's broader portfolio of multi-specific biologics.

02

Targets

CD3 (T-cell surface glycoprotein CD3)LAG3 (Lymphocyte activation Gene-3 protein)DLL3 (Delta-like ligand 3)

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