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ANTG-ASC + fibrin glue
- Development stage
- Unknown
- Lead developer
- Anterogen
- Modality
- Stem Cell Therapies → Cell Therapies, Blood Coagulation Factors → Therapeutic Enzymes → Recombinant Proteins and Enzymes
- Administration
- Intralesional
01
Overview
ANTG-ASC + fibrin glue is an investigational, locally administered combination therapy developed by Anterogen for Crohn's fistula, including complex perianal fistulas. It combines patient-derived, culture-expanded autologous adipose-derived mesenchymal stromal cells with fibrin glue, which serves as a local sealing and cell-retention matrix within the fistula tract. The cellular component is intended to promote fistula healing through local immunomodulatory, anti-inflammatory, trophic, and tissue-repair activities, while the fibrin matrix provides a scaffold for localized delivery. Anterogen's randomized Phase 3 study, ANTG-ASC-301, compares the ASC-plus-fibrin-glue regimen with fibrin glue alone in patients with Crohn's fistula. ([clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04612465))
- Brand names
- Cupistem
- Other names
- autologous adipose-derived mesenchymal stromal cells + fibrin glueautologous adipose-derived stem cells + fibrin glue
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