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anthracycline + CMF
- Development stage
- Unknown
- Modality
- Small Molecules
- Administration
- Intravenous, Oral
01
Overview
Anthracycline + CMF refers to a combination chemotherapy regimen typically used in the adjuvant treatment of breast cancer. The regimen consists of an anthracycline (commonly doxorubicin or epirubicin, which are DNA-intercalating agents that inhibit topoisomerase II and generate free radicals) administered in sequence or combination with CMF—a standard regimen containing cyclophosphamide (an alkylating agent), methotrexate (a folate antagonist), and fluorouracil (an antimetabolite). This combination leverages multiple cytotoxic mechanisms to improve disease-free and overall survival compared to CMF alone[1][3][5][6]. The precise scheduling (concurrent or sequential) and choice of anthracycline and dose may vary across protocols.
- Other names
- anthracycline plus CMFanthracycline-containing regimen plus CMFanthracycline-based regimen plus CMF
02
Targets
TOP2A (DNA topoisomerase II)TS (Thymidylate synthase)DNADHFR (Dihydrofolate reductase)
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