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anthrax rPA vaccine
- Development stage
- Phase 2
- Lead developer
- GC Biopharma
- Modality
- Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics
- Administration
- Intramuscular, Subcutaneous
01
Overview
Anthrax rPA vaccine is an investigational recombinant protein vaccine consisting of purified recombinant protective antigen (rPA) from Bacillus anthracis designed to elicit high-titer neutralizing antibodies that block protective antigen binding and pore formation required for entry of lethal and edema toxins into host cells. As a next-generation anthrax vaccine, it was developed to improve immunogenicity, consistency of manufacturing, and safety compared with cell-free filtrate anthrax vaccine adsorbed (AVA), and has been evaluated primarily for pre‑ and post‑exposure prophylaxis against inhalational anthrax in adults at risk of exposure to Bacillus anthracis.
- Brand names
- SparVax
- Other names
- recombinant protective antigen anthrax vaccinerPA anthrax vaccinerecombinant protective antigen vaccinerecombinant anthrax vaccinerecombinant protective antigen Bacillus anthracis vaccine
02
Targets
ANTXR1 (Anthrax toxin receptor 1)ANTXR2 (Anthrax toxin receptor 2)
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