anthrax vaccine precipitated

UK Anthrax Vaccine (also known as Anthrax Vaccine Precipitated or AVP) is an acellular, monovalent vaccine licensed in the United Kingdom for active immunization against anthrax, caused by *Bacillus anthracis*. It is manufactured by Porton Biopharma on behalf of the UK Government for occupational health and biodefense purposes. The vaccine is prepared from a sterile filtrate of an alum-precipitated culture supernatant of the avirulent, non-encapsulated Sterne strain (34F2) of *B. anthracis*. Unlike the US-licensed Anthrax Vaccine Adsorbed (AVA), which primarily contains protective antigen (PA), AVP contains all three components of the anthrax toxin complex: protective antigen (PA, ~65%), lethal factor (LF, ~8%), and edema factor (EF, ~3%). It is adjuvanted with aluminium potassium sulphate and administered via intramuscular injection in a primary course of four doses followed by annual boosters.

Other names

Anthrax Vaccine (Alum Precipitated Sterile Filtrate)Anthrax Vaccine PrecipitatedAnthrax antigens (alum precipitated sterile filtrate)AVPBritish anthrax vaccineUK Anthrax Vaccine