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anti-ALPP CAR-T cells
- Development stage
- Unknown
- Lead developer
- Xinqiao Hospital
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
Anti-ALPP CAR-T cells is an investigational autologous chimeric antigen receptor (CAR) T-cell therapy developed by Xinqiao Hospital of Chongqing for the treatment of advanced solid tumors. The therapy involves the genetic modification of a patient's own T cells using a retroviral vector to express a CAR that specifically targets alkaline phosphatase, placental (ALPP), a tumor-associated antigen. Following ex vivo expansion, the engineered cells are reinfused into the patient after a lymphodepleting conditioning regimen of cyclophosphamide and fludarabine. The treatment aims to induce T-cell mediated destruction of ALPP-expressing cancer cells and is currently being evaluated in a Phase 1/2 clinical trial.
- Other names
- anti-ALPP CART-cellsRetroviral vector-transduced autologous T cells to express anti-ALPP CARs
02
Targets
ALPP (Alkaline phosphatase, placental type)
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