anti-AMA1 human monoclonal antibodies

Anti-AMA1 human monoclonal antibodies are a class of therapeutic antibodies that target Apical Membrane Antigen 1 (AMA1), a highly polymorphic surface protein essential for host cell invasion by malaria parasites such as *Plasmodium falciparum* and *Plasmodium vivax*. AMA1 typically interacts with rhoptry neck protein 2 (RON2) to facilitate merozoite entry into red blood cells. While traditional anti-AMA1 antibodies block this direct interaction, recent research has identified strain-transcending human monoclonal antibodies (such as clones 75B10 and 75C8) that neutralize parasites through alternative mechanisms, such as preventing the displacement of the domain II loop or binding to novel conformational epitopes. These antibodies are being developed by organizations like the National Institute of Allergy and Infectious Diseases (NIAID) as passive immunotherapies and to guide structure-based vaccine design.

Other names

AMA1-specific human monoclonal antibodiesAMA-1-specific human monoclonal antibodiesAMA 1-specific human monoclonal antibodiesanti-AMA1 hmAbsanti-AMA-1 hmAbsanti-AMA 1 hmAbsanti-apical membrane antigen 1 human monoclonal antibodies