anti-CD103 blocking antibody

An anti-CD103 blocking antibody is a monoclonal antibody designed to target and block CD103 (integrin alpha E, encoded by the ITGAE gene). CD103 is expressed on specific T cell subsets, including CD8+ tissue-resident memory T cells and regulatory T cells, as well as dendritic cells. It binds to E-cadherin on epithelial cells to mediate cell adhesion, retention, and localized immune responses. In preclinical models, blockade of CD103 has been investigated for its potential to accelerate recovery and reduce pro-fibrotic gene expression after severe acute kidney injury (AKI), and to modulate immune responses in transplantation, inflammatory bowel disease, and oncology.

Other names

CD103 blocking antibodyCD-103 blocking antibodyCD 103 blocking antibodyCD103-blocking antibodyCD-103-blocking antibodyCD 103-blocking antibodyanti-CD103 antibodyanti-CD-103 antibodyanti-CD 103 antibody