anti-CD40 ligand scFv-mFc

A recombinant **anti-CD40 ligand antibody fragment fused to a murine Fc domain**. Based on the name, this agent is best understood as an experimental **CD40 ligand blocking immunomodulatory fusion antibody**, in which an scFv directed against CD40 ligand is linked to an mFc region to improve stability, avidity, and half-life relative to a naked scFv. Its intended mechanism would be antagonism of the **CD40 ligand CD40 signaling axis** by binding CD40 ligand on activated immune cells and thereby reducing downstream costimulatory immune activation. However, the exact molecular construct, developer, indication, species specificity, and development history could not be established with confidence from the available evidence, so this entry should be treated as a minimally resolved experimental biologic rather than a well-characterized named drug candidate.

Other names

anti-CD40 ligand scFv-mFcanti-CD-40 ligand scFv-mFcanti-CD 40 ligand scFv-mFcanti-CD40L scFv-mFcanti-CD-40L scFv-mFcanti-CD 40L scFv-mFcanti-CD154 scFv-mFcanti-CD-154 scFv-mFcanti-CD 154 scFv-mFc