anti-CEA-Alexa 488

anti-CEA-Alexa 488 is a fluorescently labeled monoclonal antibody conjugate designed for fluorescence-guided surgery (FGS). It consists of a monoclonal antibody specific for carcinoembryonic antigen (CEA) covalently linked to the Alexa Fluor 488 fluorophore. CEA is a cell-surface glycoprotein that is overexpressed in several solid tumors, including pancreatic and colorectal cancers. By binding to CEA-expressing cells, the conjugate allows for the real-time identification and localization of primary tumors and sub-millimeter metastatic lesions using fluorescence laparoscopy. This technology is intended to assist surgeons in achieving complete tumor resection and identifying margins that are not visible under standard bright-light conditions. The agent has been primarily investigated in preclinical orthotopic mouse models of human pancreatic cancer by OncoFluor and researchers at the University of California San Diego.

Other names

anti-CEA-Alexa Fluor 488CEA antibodies conjugated to Alexa 488