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anti-CEA CAR-T cells (Sorrento Therapeutics)
- Development stage
- Unknown
- Lead developer
- Sorrento Therapeutics
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Gene Therapies
- Administration
- Intraperitoneal
01
Overview
Anti-CEA CAR-T cells (Sorrento Therapeutics) is an autologous chimeric antigen receptor (CAR) T-cell therapy designed to target cells expressing carcinoembryonic antigen (CEA). CEA is a cell surface glycoprotein that is frequently overexpressed in various adenocarcinomas, including colorectal, pancreatic, gastric, and breast cancers. The therapy involves the genetic modification of a patient's own T cells to express a CAR construct specific for CEA. These engineered T cells are expanded ex vivo and then re-introduced into the patient via intraperitoneal infusion. This localized delivery method is specifically intended to treat peritoneal carcinomatosis, peritoneal metastases, and malignant ascites by allowing the CAR-T cells to directly interact with tumor deposits within the peritoneal cavity, potentially increasing local efficacy while minimizing systemic toxicities.
- Other names
- anti-CEA CAR-T cellsCEA CAR-Tanti-CEA intraperitoneal CAR-T infusions
02
Targets
CEACAM5 (Carcinoembryonic antigen related cell adhesion molecule 5)HLA-A*02 (HLA class I histocompatibility antigen, A alpha chain)
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