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anti-CEACAM1 monoclonal antibody
- Development stage
- Preclinical
- Lead developer
- Trellis Bioscience
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous, Intraperitoneal
01
Overview
Trellis Bioscience is developing a native human monoclonal antibody targeting CEACAM1 (carcinoembryonic antigen-related cellular adhesion molecule 1) for the treatment of cancer. Discovered using the company's proprietary CellSpot platform, which identifies high-affinity antibodies from the memory B-cells of healthy human donors, this antibody functions as an immune checkpoint modulator. CEACAM1 is an inhibitory molecule expressed on various tumor types as well as on T cells and Natural Killer (NK) cells. Its interaction suppresses immune cell activation and allows tumors to evade immune surveillance. By blocking these immunosuppressive interactions, the antibody aims to enhance anti-tumor immune responses. The program is currently in preclinical development.
- Other names
- anti-CEACAM1 mAbanti-CEACAM-1 mAbanti-CEACAM 1 mAbCEACAM1-monoclonal antibodyCEACAM-1-monoclonal antibodyCEACAM 1-monoclonal antibody
02
Targets
CEACAM1
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