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anti-citrullinated SR-A peptide antibody

Development stage: Preclinical
Modality: Antibody-Based Therapeutics
Administration: Intravenous

Overview

Anti-CSP (anti-citrullinated SR-A peptide antibody) is an autoantibody targeting the citrullinated scavenger receptor-A (SR-A) peptide, specifically the 305-325 epitope. Identified as a novel biomarker for rheumatoid arthritis (RA), it is particularly valuable for diagnosing patients who are negative for traditional markers such as anti-cyclic citrullinated peptide (anti-CCP) and rheumatoid factor (RF). Beyond its diagnostic utility, anti-CSP plays a pathogenic role in the disease by promoting inflammation in cartilage and exacerbating arthritis severity, as demonstrated in cartilage organoids and experimental mouse models. The antibody exhibits distinct glycosylation patterns in RA patients and its presence is associated with increased disease activity.

Other names: anti-citrullinated SR-A peptide 305-325 antibodyanti-citrullinated scavenger receptor-A peptide antibody

Targets

MSR1 (Amyloid beta precursor protein binding family B member 3)

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