Drug intelligence / Profile preview

anti-CLDN6 bispecific antibody

Development stage
Unknown
Lead developer
Context Therapeutics
Modality
T-cell Engagers → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
Administration
Intravenous
01

Overview

**Anti-CLDN6 bispecific antibody** is a non-specific descriptor that can refer to multiple investigational antineoplastic biologics directed against **claudin 6**, most notably **CLDN6 x CD3 T-cell-engaging bispecific antibodies** such as CTIM-76, BNT142, and AMG 794. These agents are being developed for **CLDN6-positive solid tumors** including ovarian, endometrial, and testicular cancers. Their intended mechanism is to bind **CLDN6** on tumor cells and **CD3** on T cells, thereby redirecting T-cell cytotoxicity toward CLDN6-expressing cancer cells. Because the query does not identify a single molecule, developer, construct format, and development stage cannot be assigned to one unique drug with confidence.

Other names
CLDN6 bispecific antibodyCLDN-6 bispecific antibodyCLDN 6 bispecific antibodyCLDN6-directed T cell-engaging bispecific antibodyCLDN-6-directed T cell-engaging bispecific antibodyCLDN 6-directed T cell-engaging bispecific antibodyCLDN6 x CD3 bispecific antibodyCLDN-6 x CD3 bispecific antibodyCLDN 6 x CD3 bispecific antibodyanti-CD3 anti-CLDN6 bispecific antibodyanti-CD-3 anti-CLDN6 bispecific antibodyanti-CD 3 anti-CLDN6 bispecific antibodyclaudin-6 bispecific antibodyclaudin6 bispecific antibodyclaudin 6 bispecific antibody
02

Targets

CD3 (T-cell surface glycoprotein CD3)CLDN6 (Claudin-6)

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