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anti-D immunoglobulin
- Development stage
- Unknown
- Lead developer
- CSL Behring
- Modality
- Antibody-Based Therapeutics
- Administration
- Intramuscular, Intravenous
01
Overview
Rh(D) immunoglobulin (also known as anti-D immunoglobulin) is a biologic drug consisting of human-derived IgG antibodies directed against the RhD antigen on red blood cells. It is prepared from the plasma of RhD-negative donors who have been immunized against the RhD antigen. The drug is primarily used to prevent RhD alloimmunization (sensitization) in RhD-negative pregnant women carrying an RhD-positive fetus, thereby preventing hemolytic disease of the fetus and newborn (HDFN). It is also indicated for the treatment of immune thrombocytopenic purpura (ITP) in RhD-positive individuals and to prevent sensitization after incompatible blood transfusions. Rh(D) immunoglobulin works by binding to and neutralizing fetal RhD-positive red blood cells that enter the maternal circulation, preventing the maternal immune system from recognizing them and producing antibodies.
- Brand names
- Rh(D) immunoglobulin-VFRhophylacRhoGAMRhocloneIgamadRhesogam NResoglobinHyperRHOWinRho SDF
- Other names
- Rh(D) immunoglobulinanti-D (Rh) immunoglobulinRho(D) immune globulinRho(D) immune globulin (human)anti-D IgGanti-D Rho immunoglobulin
02
Targets
FCGR2B (Fc gamma receptor IIB)FCGR1A (High affinity immunoglobulin gamma fc receptor I)FCGR3A (Low affinity immunoglobulin gamma Fc region receptor III-A)FCGR2A (Low affinity immunoglobulin gamma Fc receptor II-a)
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