anti-FAP Fc fusion

Anti-FAP Fc fusion proteins represent a class of engineered biologics designed to target the fibroblast activation protein (FAP), which is highly overexpressed on cancer-associated fibroblasts (CAFs) within the tumor microenvironment of most solid tumors. These molecules typically consist of a FAP-binding domain (such as a single-chain variable fragment or a Fab fragment) fused to an immunoglobulin Fc region, which may further be conjugated to effector moieties like cytokines (e.g., IL-2, IL-15) or costimulatory ligands (e.g., 4-1BBL, CD40L). The primary mechanism of action involves the selective accumulation of the therapeutic payload in the tumor stroma, thereby enhancing local immune activation while minimizing systemic toxicity. This approach is being extensively explored in oncology to turn 'cold' tumors 'hot' by modulating the immunosuppressive stroma and promoting T-cell infiltration and activation.

Other names

FAP-targeted Fc fusion proteinanti-FAP fusion proteinFAP-Fc fusion