anti-FGF-21 antibody

Anti-FGF-21 antibody refers to a **monoclonal antibody targeting fibroblast growth factor 21 (FGF-21)**. FGF-21 is a hormone primarily produced in the liver, acting as a metabolic regulator implicated in glucose uptake, lipid metabolism, and insulin sensitivity. Neutralizing anti-FGF-21 antibodies, such as the humanized monoclonal antibody clone 2D8, bind to FGF-21, inhibiting its interaction with receptors, thereby reducing its biological activity. For example, the 2D8 anti-hFGF-21 monoclonal antibody reduces FGF-21-dependent glucose uptake and GLUT1 expression in adipocyte models, indicating **neutralizing activity**. These antibodies are being explored as research tools to interrogate FGF-21 function and as potential therapeutics for diseases related to FGF-21 signaling, though clinical development is early[1].

Other names

anti-FGF21 antibodyanti-FGF-21 antibodyanti-FGF 21 antibodyanti-hFGF-21 antibodyanti-hFGF21 antibodyanti-hFGF 21 antibodyanti-human FGF-21 monoclonal antibody