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anti-GD2 CAR-T cells coexpressing GITRL
- Development stage
- Preclinical
- Lead developer
- T Cell Nouveau
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Gene Therapies
- Administration
- Intravenous
01
Overview
Anti-GD2 CAR-T cells coexpressing GITRL is an experimental cell therapy designed to treat solid tumors, specifically glioblastoma. It consists of T cells genetically engineered to express a chimeric antigen receptor (CAR) targeting the ganglioside GD2, along with the glucocorticoid-induced TNFR-related protein ligand (GITRL). The co-expression of GITRL is intended to enhance CAR-T cell potency by engaging the GITR receptor, which promotes T-cell activation, reduces exhaustion (lowering PD-1 and LAG-3 expression), and counteracts the immunosuppressive effects of regulatory T cells (Tregs) within the tumor microenvironment. Preclinical studies in glioblastoma models have demonstrated improved functional persistence and metabolic characteristics compared to standard anti-GD2 CAR-T cells.
- Other names
- anti-GD2 chimeric antigen receptor T cells coexpressing GITR ligandanti-GD-2 chimeric antigen receptor T cells coexpressing GITR ligandanti-GD 2 chimeric antigen receptor T cells coexpressing GITR ligandGD2-GITRL CAR-TGD-2-GITRL CAR-TGD 2-GITRL CAR-T
02
Targets
TNFRSF18 (GITR)GD2
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