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The Anti-H1N1v Vaccine refers to the monovalent pandemic influenza A (H1N1) 2009 vaccine used during the 2009-2010 pandemic. In the context of clinical research conducted by the Institut National de la Santé Et de la Recherche Médicale (INSERM) in France, specifically the FLU-HOP study (NCT00988312), this vaccine was evaluated for its immunologic efficacy and cross-reactivity in healthcare workers. The vaccine works by inducing neutralizing antibodies and cellular immune responses against the viral hemagglutinin protein of the A/H1N1pdm09 strain. The INSERM study specifically investigated the intensity of the immune response relative to age and prior seasonal influenza vaccinations, as well as the level of cellular and humoral cross-reactivity between different H1N1 strains.
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