Drug intelligence / Profile preview

anti-Helicobacter pylori IgY antibodies + omeprazole + amoxicillin + clarithromycin

Development stage
Unknown
Lead developer
Mashhad University of Medical Sciences
Modality
Antibody-Based Therapeutics, Small Molecules
Administration
Oral
01

Overview

This therapeutic regimen is a combination therapy developed by Mashhad University of Medical Sciences for the eradication of *Helicobacter pylori* infection. It consists of oral anti-*H. pylori* IgY antibodies, administered as egg yolk powder, used as an adjunct to a standard triple therapy comprising the proton pump inhibitor omeprazole and the antibiotics amoxicillin and clarithromycin. The IgY antibodies, derived from the egg yolks of immunized hens, provide passive immunity by binding to bacterial surface antigens, which inhibits the adhesion of *H. pylori* to the gastric mucosa and potentially neutralizes bacterial virulence factors. This combination approach is intended to enhance the bacterial eradication rate and improve clinical symptoms in patients suffering from gastritis or peptic ulcers associated with *H. pylori* infection.

Other names
anti-H. pylori IgY antibodiesIgY Antibodies in Egg Yolk for Helicobacter PyloriHelicobacter pylori eradication therapy-Mashhad University of Medical Sciences-Helicobacter pylori infection
02

Targets

Helicobacter pylori surface antigens23S rRNA (23S ribosomal RNA)ATP4A (Potassium–transporting ATPase alpha chain 1)

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