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anti-hepatitis d virus antibody

Development stage: Unknown
Lead developer: Region Midtjylland
Modality: Monoclonal Antibodies → Antibody-Based Therapeutics
Administration: Intravenous

Overview

Anti-hepatitis D virus antibody is a human monoclonal antibody developed by Region Midtjylland (specifically researchers at Aarhus University Hospital) for the treatment of chronic hepatitis D virus (HDV) infection. HDV is a satellite virus that requires the presence of hepatitis B virus (HBV) to infect hepatocytes, as it utilizes HBV surface antigens for its envelope. This antibody, specifically identified as MA17/7 in research, targets the Pre-S1 domain of the large hepatitis B surface protein (L-HBsAg) on the viral envelope. By binding to this domain, the antibody neutralizes HDV particles and blocks their interaction with the sodium taurocholate cotransporting polypeptide (NTCP) receptor, thereby preventing viral entry into host cells. It is currently being evaluated in Phase 1 clinical trials to assess its safety, tolerability, and antiviral efficacy in patients with chronic HDV.

Other names: Anti-HDV mAbHuman monoclonal antibody against hepatitis D virus

Targets

LHBs (Hepatitis B virus large surface protein)

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