Drug intelligence / Profile preview

anti-HER-2 x HBsAg

Development stage
Preclinical
Lead developer
Phoenix Biomolecular Engineering Foundation
Modality
Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
01

Overview

**anti-HER-2 x HBsAg** refers to a bispecific monoclonal antibody designed to target both the human epidermal growth factor receptor 2 (HER2) and hepatitis B surface antigen (HBsAg). The HER2-binding arm is intended to target HER2-positive cancer cells, while the HBsAg-binding arm either targets hepatitis B virus-infected cells or uses HBsAg as a carrier/target for immune modulation. Bispecific antibodies such as this have applications in oncology, viral hepatitis, or as research tools. The specific mechanism is dual: inhibiting HER2-driven tumor growth and interacting with HBsAg. This agent is not listed among approved pharmaceuticals or clinical-stage drugs; it is likely a research or preclinical candidate. Mechanism: HER2 arm blocks HER2-mediated signaling and may cause antibody-dependent cellular cytotoxicity; HBsAg arm may support immune targeting of HBV-infected cells or serve as an antigen tether.

Brand names
anti-HER-2 x HBsAganti-HER2 x HBsAganti-HER 2 x HBsAg
Other names
anti-HER-2 x HBsAganti-HER2 x HBsAganti-HER 2 x HBsAg
02

Targets

HBsAg (Hepatitis B surface antigen)ERBB2 (Erb-b2 receptor tyrosine kinase 2)

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