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anti-HER2-CAR-T cell (China Medical University)
- Development stage
- Unknown
- Lead developer
- China Medical University
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
Anti-HER2-CAR-T cell therapy is an autologous cellular immunotherapy consisting of T cells genetically engineered to express a chimeric antigen receptor (CAR) that specifically targets the Human Epidermal Growth Factor Receptor 2 (HER2). HER2 is a tyrosine kinase receptor that is frequently overexpressed in various solid tumors, including breast, gastric, and lung cancers, where it promotes cell proliferation and survival. Upon administration, these engineered T cells recognize and bind to HER2-expressing tumor cells, leading to T-cell activation, the release of cytotoxic cytokines, and the direct lysis of the cancer cells. This specific program is being investigated by China Medical University in Phase 1 clinical trials for patients with HER2-positive locally advanced or metastatic solid tumors.
- Other names
- Anti-HER2-CAR-T Cells InjectionAnti-HER-2-CAR-T Cells InjectionAnti-HER 2-CAR-T Cells Injection
02
Targets
ERBB2 (Erb-b2 receptor tyrosine kinase 2)
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