anti-hIL-6R antibody

An anti-hIL-6R antibody is a monoclonal antibody designed to target and bind to the human interleukin-6 receptor (hIL-6R), which exists in both soluble (sIL-6R) and membrane-bound (mIL-6R) forms. By binding to hIL-6R, the antibody prevents the pro-inflammatory cytokine interleukin-6 (IL-6) from interacting with its receptor and initiating the gp130 signaling cascade. This inhibition blocks both classical signaling (via mIL-6R) and trans-signaling (via sIL-6R) pathways, which are key drivers of chronic inflammation, autoimmune diseases, and cytokine release syndromes. Several therapeutic antibodies in this class, such as tocilizumab, sarilumab, and satralizumab, have been developed and approved for various inflammatory and autoimmune conditions.

Other names

IL-6R antibodyIL6R antibodyIL 6R antibodyIL-6R blockerIL6R blockerIL 6R blockerIL-6R inhibitorIL6R inhibitorIL 6R inhibitoranti-IL-6R antibodyanti-IL6R antibodyanti-IL 6R antibodyanti-human IL-6 receptor antibodyanti-human interleukin-6 receptor antibody