anti-Hla neutralizing antibody

Anti-Hla neutralizing antibodies (often misspelled as anti-HLA neutralization antibodies) are a class of monoclonal or polyclonal antibodies that target and neutralize the alpha-toxin (alpha-hemolysin, Hla) secreted by *Staphylococcus aureus*. Alpha-toxin is a key virulence factor that forms heptameric pores in host cell membranes (such as red blood cells, platelets, and endothelial cells) by binding to its cellular receptor, ADAM10, leading to cell lysis and tissue damage. By binding to Hla, these neutralizing antibodies prevent pore formation and protect host tissues from toxin-mediated injury. This therapeutic approach is being investigated for the prevention and treatment of *S. aureus* infections, including skin and soft tissue infections (SSTIs) and pneumonia, as an alternative or adjunct to traditional antibiotics.

Other names

anti-HLA neutralization antibodyanti-HLA neutralizing antibodyanti-Hla neutralizing antibodiesanti-alpha-hemolysin neutralizing antibodyanti-alpha-toxin neutralizing antibody