Drug intelligence / Profile preview

anti-hPD-L1

Development stage
Preclinical
Lead developer
InvivoGen
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics
Administration
Intraperitoneal, Intravenous, Intratumoral
01

Overview

Anti-hPD-L1 is a research-grade monoclonal antibody developed by InvivoGen for use in preclinical mouse models. It features a variable region identical to that of atezolizumab, a fully humanized IgG1 antibody targeting human Programmed Death-Ligand 1 (PD-L1). By blocking the PD-L1/PD-1 signaling pathway, the antibody prevents tumor cells from evading immune detection. InvivoGen offers several isotype variants, including anti-hPD-L1-mIgG1 (containing a mouse IgG1 Fc region to reduce immunogenicity in murine studies) and anti-hPD-L1-hIgG1 (an atezolizumab biosimilar). These reagents are intended for laboratory research only and are not approved for human therapeutic or diagnostic use.

Other names
anti-hPDL1anti-hPDL-1anti-hPDL 1anti-human PD-L1 antibodyanti-human PD-L1
02

Targets

CD274 (Programmed cell death protein 1 ligand 1)

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