anti-ICAM antibody

An anti-ICAM antibody (specifically targeting Intercellular Adhesion Molecule 1, or ICAM-1/CD54) is a monoclonal antibody designed to inhibit the interaction between ICAM-1 on endothelial cells and its ligands (such as LFA-1) on leukocytes. This blockade prevents leukocyte adhesion and transendothelial migration, thereby reducing inflammation and tissue damage in conditions like ischemia-reperfusion injury, stroke, and autoimmune diseases. Several anti-ICAM-1 antibodies, such as enlimomab and bersanlimab, have been investigated in clinical trials for indications including acute ischemic stroke, rheumatoid arthritis, renal transplantation, and multiple myeloma, though clinical efficacy has been limited.

Other names

anti-CD54 antibodyanti-CD-54 antibodyanti-CD 54 antibodyanti-ICAM monoclonal antibodyanti-ICAM-1 antibodyanti-ICAM1 antibodyanti-ICAM 1 antibodyanti-ICAM-1 monoclonal antibodyanti-ICAM1 monoclonal antibodyanti-ICAM 1 monoclonal antibodyanti-intercellular adhesion molecule-1 antibody