anti-ICP1 monoclonal antibody

The anti-ICP1 monoclonal antibody is a diagnostic monoclonal antibody designed to target the structural proteins of the Vibrio cholerae-specific virulent bacteriophage ICP1. Developed by researchers at the University of Florida in collaboration with the International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) and Incepta Pharmaceuticals, this antibody is intended for integration into cholera rapid diagnostic tests (RDTs). Phage predation by ICP1 in patient stool samples can significantly reduce the sensitivity of standard cholera RDTs by degrading the target bacteria. By incorporating monoclonal antibodies that bind to ICP1 structural proteins—such as the major capsid protein (ORF122), capsid decoration protein (ORF123), and tail fiber proteins (ORF69 and ORF93)—the diagnostic test can detect the phage as a proxy for V. cholerae infection, thereby improving the overall sensitivity and durability of cholera diagnostics in the field.

Other names

ORF122 mAbORF-122 mAbORF 122 mAbORF123 mAbORF-123 mAbORF 123 mAbORF93 mAbORF-93 mAbORF 93 mAbanti-ICP1 mAbanti-ICP-1 mAbanti-ICP 1 mAbanti-ICP1 major capsid protein monoclonal antibodyanti-ICP-1 major capsid protein monoclonal antibodyanti-ICP 1 major capsid protein monoclonal antibodyanti-ICP1 major head protein monoclonal antibodyanti-ICP-1 major head protein monoclonal antibodyanti-ICP 1 major head protein monoclonal antibody