anti-insulin receptor monoclonal antibody 83-7

Anti-insulin receptor monoclonal antibody 83-7 is a murine monoclonal antibody (IgG1) that acts as a partial agonist of the human insulin receptor (INSR). Developed at the University of Cambridge, it binds to a conformational epitope within the cysteine-rich region (amino acids 140-301) of the extracellular alpha-subunit of the human insulin receptor. In preclinical models of severe insulin resistance arising from insulin receptoropathies (such as Donohue syndrome or Rabson-Mendenhall syndrome), antibody 83-7 has been investigated as a surrogate agonist to stimulate receptor autophosphorylation and downstream signaling (preferentially activating the Akt pathway over ERK1/2), thereby improving glucose tolerance and reducing hyperinsulinemia. However, its therapeutic window is limited by its tendency to induce receptor downregulation.

Other names

anti-INSR monoclonal antibody 83-7anti-insulin receptor antibody 83-7clone 83-7clone83-7clone-83-7mAb 83-7mAb83-7mAb-83-7monoclonal antibody 83-7