anti-LAG-3 nanobody

An anti-LAG-3 nanobody is a single-domain antibody (VHH) fragment derived from camelids (such as alpacas or llamas) that specifically targets Lymphocyte Activation Gene-3 (LAG-3), an inhibitory immune checkpoint receptor expressed on T cells, natural killer (NK) cells, and other immune subpopulations. By binding to LAG-3, these nanobodies block its interaction with major histocompatibility complex class II (MHC-II) molecules and other ligands, thereby preventing inhibitory signaling and restoring T-cell activation and effector functions. Due to their small size (~15 kDa), high stability, and rapid clearance, anti-LAG-3 nanobodies are being investigated both as therapeutic checkpoint inhibitors for cancer immunotherapy and as radiolabeled molecular imaging tracers (e.g., for SPECT/CT or PET/CT) to non-invasively assess LAG-3 expression in the tumor microenvironment.

Other names

LAG-3 nanobodyLAG3 nanobodyLAG 3 nanobodyLAG-3 single-domain antibodyLAG3 single-domain antibodyLAG 3 single-domain antibodyanti-LAG-3 single-domain antibodyanti-LAG3 single-domain antibodyanti-LAG 3 single-domain antibodyanti-LAG3 nanobodyanti-LAG-3 nanobodyanti-LAG 3 nanobodyanti-LAG3-Nb-Fcanti-LAG-3-Nb-Fcanti-LAG 3-Nb-Fc