anti-Loxosceles Fab antivenom

anti-Loxosceles Fab antivenom is an equine-derived, purified F(ab')2 fragment-based antivenom designed to treat envenomation caused by spiders of the genus Loxosceles (brown recluse spiders). The antivenom is produced by immunizing horses with Loxosceles venom or recombinant sphingomyelinase D (SMase D) toxins, followed by pepsin digestion of the IgG fraction to yield F(ab')2 fragments. It works by physically binding to and neutralizing sphingomyelin phosphodiesterase D, the primary dermonecrotic and hemolytic toxin in Loxosceles venom, thereby preventing tissue necrosis, hemolysis, and systemic complications such as acute kidney injury and rhabdomyolysis. It is marketed under the brand name Reclusmyn in Mexico, where it is approved for the treatment of both cutaneous and systemic loxoscelism.

Brand names

Reclusmyn

Other names

Loxosceles immune F(ab)2Loxosceles immune F(ab')2anti-Loxosceles F(ab')2anti-Loxosceles F(ab')2 antivenomanti-Loxosceles fabotherapeuticpolyvalent anti-Loxosceles F(ab')2 antivenompolyvalent anti-Loxosceles fabotherapeuticsoro antiloxoscélico