anti-müllerian hormone

Recombinant Anti-Müllerian Hormone (AMH), also known as Müllerian-Inhibiting Substance (MIS), is a protein member of the transforming growth factor-beta (TGF-β) superfamily. In female physiology, AMH is primarily produced by granulosa cells of pre-antral and small antral follicles, where it acts as a negative regulator of follicle recruitment and FSH sensitivity. As a therapeutic candidate, recombinant AMH is being investigated for its potential as a non-steroidal contraceptive and for oncofertility applications, such as protecting the ovarian reserve from chemotherapy-induced damage. In research contexts, as highlighted in recent studies, exogenous administration of recombinant AMH is used to establish animal models of Polycystic Ovary Syndrome (PCOS). These models demonstrate that elevated AMH levels can disrupt the hypothalamic-pituitary-ovarian (HPO) axis, leading to suppressed LH surges, increased LH pulse frequency, irregular estrous cycles, and impaired fertility, thereby providing a platform to study the neuroendocrine mechanisms of PCOS.

Other names

AMHMüllerian-inhibiting substanceMISrecombinant human AMHrhAMH