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anti-mouse Cd39 antibody

Development stage: Preclinical
Lead developer: Antagen Institute for Biomedical Research
Modality: Monoclonal Antibodies → Antibody-Based Therapeutics
Administration: Intravenous

Overview

The anti-mouse Cd39 antibody is an engineered monoclonal antibody designed to target murine CD39 (ectonucleoside triphosphate diphosphohydrolase-1). Developed for research in acute myeloid leukemia (AML), this antibody is specifically engineered with isotype selection and the removal of fucose (afucosylation) to enhance its interaction with Fc receptors (FcR). Its mechanism involves promoting the redistribution of CD39 from AML cells to effector immune cells through FcR-mediated trogocytosis, thereby reducing the immunosuppressive effects of CD39 and enhancing the efficacy of chemotherapeutic agents like daunorubicin in experimental models.

Other names: anti-Cd39 mAbanti-Cd-39 mAbanti-Cd 39 mAbanti-mouse CD39 monoclonal antibody

Targets

ENTPD1 (Ectonucleoside triphosphate diphosphohydrolase 1)

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