anti-mouse CTLA-4 antibody

Anti-mCTLA-4 refers to a class of monoclonal antibodies specifically designed to bind to and inhibit the murine Cytotoxic T-Lymphocyte Associated Protein 4 (CTLA-4). In the immune system, CTLA-4 acts as a critical checkpoint molecule that downregulates T-cell activation by competing with the costimulatory receptor CD28 for binding to ligands CD80 and CD86. By blocking this inhibitory pathway, anti-mCTLA-4 antibodies promote the expansion and activation of effector T-cells while potentially reducing the suppressive activity of regulatory T-cells (Tregs). These antibodies are widely utilized as research tools in syngeneic mouse tumor models (such as B16-F10 or Cloudman S91) to evaluate the efficacy of checkpoint blockade, often serving as surrogate agents for human therapeutics like ipilimumab. They are frequently studied in combination with other immunomodulators, targeted therapies, or focal radiation to overcome tumor-induced immunosuppression.

Other names

anti-mCTLA-4anti-mCTLA4anti-mCTLA 4anti-mouse CD152