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anti-mPD1 mimotope IgG
- Development stage
- Preclinical
- Lead developer
- Medical University of Vienna
- Modality
- Antibody-Based Therapeutics
- Administration
- Parenteral
01
Overview
Anti-mPD1 mimotope IgG is a preclinical rabbit-derived polyclonal antibody generated by immunizing rabbits with a B-cell mimotope of mouse programmed cell death protein 1 (mPD-1). Developed by the Medical University of Vienna in collaboration with Imugene, this antibody was designed as a proof-of-concept therapeutic to evaluate the in vivo anti-tumor efficacy of active immunization targeting PD-1. In preclinical studies, anti-mPD1 mimotope IgG successfully blocked the interaction between mPD-1 and its ligand mPD-L1, leading to significant tumor growth reduction in syngeneic mouse models of HER2-positive breast cancer.
- Other names
- anti-mPD-1 mimotope IgGanti-mPD1 mimotope IgGanti-mPD 1 mimotope IgGanti-mPD1 mimotope antibodyanti-mPD-1 mimotope antibodyanti-mPD 1 mimotope antibodyanti-mouse PD-1 mimotope IgG
02
Targets
PDCD1 (Programmed cell death protein 1 receptor)
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