anti-murine IL-18

The term "anti-murine IL-18" refers to a class of monoclonal antibodies designed to neutralize the pro-inflammatory cytokine interleukin-18 (IL-18) in murine models. A specific example identified in preclinical research is **SK113AE-4**, a neutralizing antibody developed by **Novartis**. In studies of sickle cell disease (SCD) using Townes mice, SK113AE-4 has been shown to significantly reduce TNF-α-induced leukocyte recruitment, adhesion, and extravasation in the microvasculature. It also reduces the production of interferon-gamma (IFN-γ), a cytokine synergistically regulated by IL-18 and IL-12. While primarily used as a research tool to validate the IL-18 pathway in inflammatory diseases, these antibodies provide proof-of-concept for targeting inflammasome-processed cytokines in conditions like SCD and other chronic inflammatory states.

Other names

anti-murine IL-18anti-mIL-18anti-mIL18anti-mIL 18