anti-murine PD-1

Anti-murine PD-1 is a monoclonal antibody used in preclinical research to block the Programmed Cell Death Protein 1 (PD-1) receptor in mouse models. It is a standard tool for investigating the effects of immune checkpoint blockade in syngeneic tumor models, such as the AB1B mesothelioma model. By preventing the interaction between PD-1 and its ligands, PD-L1 and PD-L2, the antibody enhances T-cell mediated anti-tumor activity. In the provided context, it was used both as a monotherapy and in combination with an ADORA2B inhibitor (TT4) to demonstrate synergistic anti-tumor effects and increased immune cell infiltration in mesothelioma-bearing mice.

Other names

anti-mouse PD-1anti-mPD-1anti-mPD1anti-mPD 1