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anti-Neu monoclonal antibody
- Development stage
- Unknown
- Lead developer
- University of Pennsylvania
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intraperitoneal, Intravenous
01
Overview
Anti-Neu monoclonal antibody refers to a class of monoclonal antibodies that target Neu, the rodent homolog of human epidermal growth factor receptor 2 (HER2/ErbB2). In preclinical research, these antibodies (most notably clone 7.16.4) are widely used to study HER2-positive breast cancer and tumor immunology in mouse models, as humanized anti-HER2 antibodies like trastuzumab do not cross-react with rodent Neu. These antibodies bind to the extracellular domain of Neu, inhibiting tumor cell proliferation and mediating anti-tumor immune responses through mechanisms such as antibody-dependent cellular cytotoxicity (ADCC) and T-cell activation.
- Other names
- 7.16.4anti-HER2/neu monoclonal antibodyanti-rat Neu monoclonal antibodyclone 7.16.4clone7.16.4clone-7.16.4
02
Targets
ERBB2 (Erb-b2 receptor tyrosine kinase 2)
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