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Anti NME7 Monoclonal Antibody
- Development stage
- Preclinical
- Lead developer
- Minerva Biotechnologies
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
Anti NME7 Monoclonal Antibody is a therapeutic antibody under preclinical development for the treatment of solid tumor cancers. It targets the onco-embryonic growth factor NME7AB, a cleaved form of the NME7 protein. NME7 is a multifunctional enzyme involved in microtubule nucleation and ciliary function. In cancer, NME7 expression is mistakenly reactivated, and its cleaved form, NME7AB, binds to the MUC1* growth factor receptor, activating the MAP kinase signaling cascade and promoting metastasis. This monoclonal antibody is designed to disrupt the interaction between NME7AB and MUC1*, thereby inhibiting tumor growth and metastasis.
- Other names
- Anti-NME7Anti-NME-7Anti-NME 7Anti-NME7ABAnti-NME-7ABAnti-NME 7AB
02
Targets
NME7 (NME/NM23 family member 7)
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